Informatics Publishing Limited

N. S. Dighe ¹, S. R. Pattan ¹, S. B . Dighe ¹, S. B. Bhawar ¹, R. B. Saudagar ², V. M. Gaware ¹, M. B. Hole ¹, V. B. Tambe ¹

Affiliations
1 Pravara Rural College of Pharmacy, Pravaranagar, A/P-Loni (413736), Tal- Rahata, Dist.-Ahmednagar, Maharashtra, IN
2 R. G. Sapakal College of Pharmacy, Nasik, Maharashtra, IN

Abstract

Chikungunya virus is an insect-borne virus, of the genus Alphavirus, that is transmitted to humans by virus-carrying Aedes mosquitoes. The virus causes an illness with symptoms similar to dengue fever with an acute febrile phase of the illness which lasts only two to five days. Infection can affect the nervous system or the musculo-skeletal system. General symptoms include fever, headache, maculopapular rash, arthralgia, myalgia, photophobia and lymphadenopathy. Virus isolation provides the most definitive diagnosis. The most effective means of prevention are protection against contact with the disease-carrying mosquitoes and mosquito control. NSAIDs, chloroquine and DNA vaccine are the effective medicines.

Keywords

Chikungunya, Aedes Mosquitoes, Fever, Chloroquine.

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N. S. Dighe ¹, S. R. Pattan ¹, S. A. Nirmal ², R. S. Kalkotwar ¹, V. M. Gaware ¹, M. B. Hole ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni (413736), Maharashtra, IN
2 Department of Pharmacognosy, Pravara Rural College of Pharmacy, Loni (413736), Maharashtra, IN

Abstract

Tamarindus indica (Caesalpiniaceae) bark is used in the treatment of pain traditionally, present work was undertaken to prove this scientifically by using suitable animal screening models as hot plate test and acetic acid induced writing test at the dose of 50 mg/kg, i.p. Petroleum ether extract showed significant increase in reaction time as compared to other extracts. Preliminary phytochemical test showed presence of sterols and triterpenes in the extract; hence these compounds might be responsible for analgesic activity.

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S. R. Pattan ¹, N. S. Dighe ¹, H. V. Shinde ¹, M. B. Hole ¹, V. M. Gaware ¹

Affiliations
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S, IN

Abstract

Fluorine is second smallest element in periodic table. It has many pharmacological activities with different substituted heterocycles. It has attracted the attention of Medicinal Chemist for its versatile and significant activities. This review explains the significance of presence of fluorine in various Medicinal compounds. The medicinal importance, use of the drugs containing fluorine is listed.

Keywords

Fluorine, Haloperidol, Progabide.

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S. R. Pattan ¹, N. S. Dighe ¹, S. V. Hiremath ², A. N. Merekar ³, V. M. Gaware ¹, D. S. Musmade ¹, P. M. Gaikwad ⁴

Affiliations
1 Dept of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
2 Dept of Pharmacology, J.N Medical College, Belgaum, IN
3 Dept of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, Loni-413713, IN
4 Dept of Pharmacology, Pd. Dr. Vitthalrao Vikhe Patil College of Pharmacy, Ahmednagar, IN

Abstract

A new series if substituted 1, 4-Dihydropyridine derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-inflammatory activity by paw edema, xylene induced ear edema and cotton wool granuloma methods. Compounds C₄, C₅, C₆, C₇ and C₉ have been found to exhibit excellent anti-inflammatory activity.

Keywords

1, 4-Dihydropyridine, Anti-Inflammatory, CHN Analysis.

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